Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 21:58, 10 November 2007 (UTC)
[edit]Proteins without matches (23)
[edit]Proteins with a High Potential Match (2)
[edit]Manual Inspection (Page not found) (16)
[edit]
Protein Status Grid - Date: 21:58, 10 November 2007 (UTC)
[edit]Vebose Log - Date: 21:58, 10 November 2007 (UTC)
[edit]- INFO: Beginning work on ABCB4... {November 10, 2007 1:31:17 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 1:32:29 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = ATP-binding cassette, sub-family B (MDR/TAP), member 4
| HGNCid = 45
| Symbol = ABCB4
| AltSymbols =; ABC21; MDR2/3; MDR3; PFIC-3; PGY3
| OMIM = 171060
| ECnumber =
| Homologene = 56421
| MGIid = 97569
| GeneAtlas_image1 = PBB_GE_ABCB4_207819_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ABCB4_209994_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008559 |text = xenobiotic-transporting ATPase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0016887 |text = ATPase activity}} {{GNF_GO|id=GO:0042626 |text = ATPase activity, coupled to transmembrane movement of substances}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0009410 |text = response to xenobiotic stimulus}} {{GNF_GO|id=GO:0042493 |text = response to drug}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5244
| Hs_Ensembl = ENSG00000005471
| Hs_RefseqProtein = NP_000434
| Hs_RefseqmRNA = NM_000443
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 86869302
| Hs_GenLoc_end = 86942991
| Hs_Uniprot = P21439
| Mm_EntrezGene = 18670
| Mm_Ensembl = ENSMUSG00000042476
| Mm_RefseqmRNA = NM_008830
| Mm_RefseqProtein = NP_032856
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 8899723
| Mm_GenLoc_end = 8965232
| Mm_Uniprot = P21440
}}
}}
'''ATP-binding cassette, sub-family B (MDR/TAP), member 4''', also known as '''ABCB4''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function.<ref>{{cite web | title = Entrez Gene: ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5244| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ATP2A1... {November 10, 2007 1:24:09 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein ATP2A1 image.jpg {November 10, 2007 1:24:48 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 1:25:00 PM PST}
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{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ATP2A1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1iwo.
| PDB = {{PDB2|1iwo}}, {{PDB2|1kju}}, {{PDB2|1su4}}, {{PDB2|1t5s}}, {{PDB2|1t5t}}, {{PDB2|1vfp}}, {{PDB2|1wpe}}, {{PDB2|1wpg}}, {{PDB2|1xp5}}, {{PDB2|2agv}}, {{PDB2|2by4}}, {{PDB2|2c88}}, {{PDB2|2c8k}}, {{PDB2|2c8l}}, {{PDB2|2c9m}}, {{PDB2|2dqs}}, {{PDB2|2ear}}, {{PDB2|2eas}}, {{PDB2|2eat}}, {{PDB2|2eau}}, {{PDB2|2o9j}}, {{PDB2|2oa0}}
| Name = ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
| HGNCid = 811
| Symbol = ATP2A1
| AltSymbols =; ATP2A; SERCA1
| OMIM = 108730
| ECnumber =
| Homologene = 7635
| MGIid = 105058
| GeneAtlas_image1 = PBB_GE_ATP2A1_205444_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0005388 |text = calcium-transporting ATPase activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0016820 |text = hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0016529 |text = sarcoplasmic reticulum}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006812 |text = cation transport}} {{GNF_GO|id=GO:0006816 |text = calcium ion transport}} {{GNF_GO|id=GO:0006942 |text = regulation of striated muscle contraction}} {{GNF_GO|id=GO:0008152 |text = metabolic process}} {{GNF_GO|id=GO:0015992 |text = proton transport}} {{GNF_GO|id=GO:0031448 |text = positive regulation of striated fast muscle contraction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 487
| Hs_Ensembl = ENSG00000196296
| Hs_RefseqProtein = XP_001127578
| Hs_RefseqmRNA = XM_001127578
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 28797310
| Hs_GenLoc_end = 28823331
| Hs_Uniprot = O14983
| Mm_EntrezGene = 11937
| Mm_Ensembl = ENSMUSG00000030730
| Mm_RefseqmRNA = NM_007504
| Mm_RefseqProtein = NP_031530
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 126238017
| Mm_GenLoc_end = 126254070
| Mm_Uniprot = Q3TUZ7
}}
}}
'''ATPase, Ca++ transporting, cardiac muscle, fast twitch 1''', also known as '''ATP2A1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in two transcript variants encoding different isoforms.<ref>{{cite web | title = Entrez Gene: ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=487| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Baba-Aissa F, Raeymaekers L, Wuytack F, ''et al.'' |title=Distribution and isoform diversity of the organellar Ca2+ pumps in the brain. |journal=Mol. Chem. Neuropathol. |volume=33 |issue= 3 |pages= 199-208 |year= 1998 |pmid= 9642673 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on AZGP1... {November 10, 2007 1:25:00 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein AZGP1 image.jpg {November 10, 2007 1:26:01 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 1:26:22 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_AZGP1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1t7v.
| PDB = {{PDB2|1t7v}}, {{PDB2|1t7w}}, {{PDB2|1t7x}}, {{PDB2|1t7y}}, {{PDB2|1t7z}}, {{PDB2|1t80}}, {{PDB2|1zag}}, {{PDB2|2icn}}
| Name = Alpha-2-glycoprotein 1, zinc-binding
| HGNCid = 910
| Symbol = AZGP1
| AltSymbols =; ZA2G; ZAG
| OMIM = 194460
| ECnumber =
| Homologene = 915
| MGIid = 103163
| GeneAtlas_image1 = PBB_GE_AZGP1_209309_at_tn.png
| GeneAtlas_image2 = PBB_GE_AZGP1_217014_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004540 |text = ribonuclease activity}} {{GNF_GO|id=GO:0005504 |text = fatty acid binding}} {{GNF_GO|id=GO:0008320 |text = protein carrier activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0042612 |text = MHC class I protein complex}}
| Process = {{GNF_GO|id=GO:0002474 |text = antigen processing and presentation of peptide antigen via MHC class I}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0016042 |text = lipid catabolic process}} {{GNF_GO|id=GO:0019882 |text = antigen processing and presentation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 563
| Hs_Ensembl = ENSG00000160862
| Hs_RefseqProtein = NP_001176
| Hs_RefseqmRNA = NM_001185
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 99402290
| Hs_GenLoc_end = 99411623
| Hs_Uniprot = P25311
| Mm_EntrezGene = 12007
| Mm_Ensembl = ENSMUSG00000037053
| Mm_RefseqmRNA = NM_013478
| Mm_RefseqProtein = NP_038506
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 138211324
| Mm_GenLoc_end = 138220018
| Mm_Uniprot = Q9DBB7
}}
}}
'''Alpha-2-glycoprotein 1, zinc-binding''', also known as '''AZGP1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on KLF5... {November 10, 2007 1:26:22 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 1:27:26 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Kruppel-like factor 5 (intestinal)
| HGNCid = 6349
| Symbol = KLF5
| AltSymbols =; BTEB2; CKLF; IKLF
| OMIM = 602903
| ECnumber =
| Homologene = 37520
| MGIid = 1338056
| GeneAtlas_image1 = PBB_GE_KLF5_209211_at_tn.png
| GeneAtlas_image2 = PBB_GE_KLF5_209212_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0030033 |text = microvillus biogenesis}} {{GNF_GO|id=GO:0045941 |text = positive regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 688
| Hs_Ensembl = ENSG00000102554
| Hs_RefseqProtein = NP_001721
| Hs_RefseqmRNA = NM_001730
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 13
| Hs_GenLoc_start = 72530931
| Hs_GenLoc_end = 72549677
| Hs_Uniprot = Q13887
| Mm_EntrezGene = 12224
| Mm_Ensembl = ENSMUSG00000005148
| Mm_RefseqmRNA = NM_009769
| Mm_RefseqProtein = NP_033899
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 98181825
| Mm_GenLoc_end = 98196556
| Mm_Uniprot = Q923C0
}}
}}
'''Kruppel-like factor 5 (intestinal)''', also known as '''KLF5''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. Since the protein localizes to the nucleus and binds the epidermal growth factor response element, it is thought to be a transcription factor.<ref>{{cite web | title = Entrez Gene: KLF5 Kruppel-like factor 5 (intestinal)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=688| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Nagai R, Suzuki T, Aizawa K, ''et al.'' |title=Significance of the transcription factor KLF5 in cardiovascular remodeling. |journal=J. Thromb. Haemost. |volume=3 |issue= 8 |pages= 1569-76 |year= 2005 |pmid= 16102021 |doi= 10.1111/j.1538-7836.2005.01366.x }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on KLK6... {November 10, 2007 1:33:43 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein KLK6 image.jpg {November 10, 2007 1:34:16 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 1:34:49 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_KLK6_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1gvl.
| PDB = {{PDB2|1gvl}}, {{PDB2|1l2e}}, {{PDB2|1lo6}}
| Name = Kallikrein-related peptidase 6
| HGNCid = 6367
| Symbol = KLK6
| AltSymbols =; ZYME; Bssp; Klk7; MGC9355; NEUROSIN; PRSS18; PRSS9; SP59; hK6
| OMIM = 602652
| ECnumber =
| Homologene = 68279
| MGIid = 1343166
| GeneAtlas_image1 = PBB_GE_KLK6_204733_at_tn.png
| Function = {{GNF_GO|id=GO:0004252 |text = serine-type endopeptidase activity}} {{GNF_GO|id=GO:0004293 |text = tissue kallikrein activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008233 |text = peptidase activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0007417 |text = central nervous system development}} {{GNF_GO|id=GO:0009611 |text = response to wounding}} {{GNF_GO|id=GO:0016540 |text = protein autoprocessing}} {{GNF_GO|id=GO:0030574 |text = collagen catabolic process}} {{GNF_GO|id=GO:0042246 |text = tissue regeneration}} {{GNF_GO|id=GO:0042445 |text = hormone metabolic process}} {{GNF_GO|id=GO:0042552 |text = myelination}} {{GNF_GO|id=GO:0042982 |text = amyloid precursor protein metabolic process}} {{GNF_GO|id=GO:0045595 |text = regulation of cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5653
| Hs_Ensembl = ENSG00000167755
| Hs_RefseqProtein = NP_001012982
| Hs_RefseqmRNA = NM_001012964
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 56153700
| Hs_GenLoc_end = 56164741
| Hs_Uniprot = Q92876
| Mm_EntrezGene = 19144
| Mm_Ensembl = ENSMUSG00000050063
| Mm_RefseqmRNA = NM_011177
| Mm_RefseqProtein = NP_035307
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 43692600
| Mm_GenLoc_end = 43699828
| Mm_Uniprot =
}}
}}
'''Kallikrein-related peptidase 6''', also known as '''KLK6''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene.<ref>{{cite web | title = Entrez Gene: KLK6 kallikrein-related peptidase 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5653| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Yousef GM, Kishi T, Diamandis EP |title=Role of kallikrein enzymes in the central nervous system. |journal=Clin. Chim. Acta |volume=329 |issue= 1-2 |pages= 1-8 |year= 2003 |pmid= 12589961 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OCA2... {November 10, 2007 1:28:55 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 1:29:44 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Oculocutaneous albinism II (pink-eye dilution homolog, mouse)
| HGNCid = 8101
| Symbol = OCA2
| AltSymbols =; BOCA; D15S12; P; PED
| OMIM = 203200
| ECnumber =
| Homologene = 37281
| MGIid = 97454
| GeneAtlas_image1 = PBB_GE_OCA2_206498_at_tn.png
| Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005302 |text = L-tyrosine transmembrane transporter activity}} {{GNF_GO|id=GO:0005395 |text = eye pigment precursor transporter activity}} {{GNF_GO|id=GO:0015105 |text = arsenite transmembrane transporter activity}} {{GNF_GO|id=GO:0015137 |text = citrate transmembrane transporter activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006726 |text = eye pigment biosynthetic process}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0007286 |text = spermatid development}} {{GNF_GO|id=GO:0015746 |text = citrate transport}} {{GNF_GO|id=GO:0048066 |text = pigmentation during development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4948
| Hs_Ensembl = ENSG00000104044
| Hs_RefseqProtein = NP_000266
| Hs_RefseqmRNA = NM_000275
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 15
| Hs_GenLoc_start = 25673628
| Hs_GenLoc_end = 26018061
| Hs_Uniprot = Q04671
| Mm_EntrezGene = 18431
| Mm_Ensembl = ENSMUSG00000030450
| Mm_RefseqmRNA = NM_021879
| Mm_RefseqProtein = NP_068679
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 56107790
| Mm_GenLoc_end = 56404536
| Mm_Uniprot = Q0VBP9
}}
}}
'''Oculocutaneous albinism II (pink-eye dilution homolog, mouse)''', also known as '''OCA2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = OCA2 encodes the human homologue of the mouse p (pink-eyed dilution) gene. The P protein is believed to be an integral membrane protein involved in small molecule transport, specifically tyrosine - a precursor of melanin. Mutations in OCA2 result in type 2 oculocutaneous albinism.<ref>{{cite web | title = Entrez Gene: OCA2 oculocutaneous albinism II (pink-eye dilution homolog, mouse)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4948| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Oetting WS, King RA |title=Molecular basis of albinism: mutations and polymorphisms of pigmentation genes associated with albinism. |journal=Hum. Mutat. |volume=13 |issue= 2 |pages= 99-115 |year= 1999 |pmid= 10094567 |doi= 10.1002/(SICI)1098-1004(1999)13:2<99::AID-HUMU2>3.0.CO;2-C }}
*{{cite journal | author=Brilliant MH |title=The mouse p (pink-eyed dilution) and human P genes, oculocutaneous albinism type 2 (OCA2), and melanosomal pH. |journal=Pigment Cell Res. |volume=14 |issue= 2 |pages= 86-93 |year= 2001 |pmid= 11310796 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PA2G4... {November 10, 2007 1:29:44 PM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 1:30:51 PM PST}
- CREATED: Created new protein page: PA2G4 {November 10, 2007 1:30:59 PM PST}
- INFO: Beginning work on PDZK1... {November 10, 2007 1:30:59 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 1:31:17 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = PDZ domain containing 1
| HGNCid = 8821
| Symbol = PDZK1
| AltSymbols =; CAP70; CLAMP; PDZD1
| OMIM = 603831
| ECnumber =
| Homologene = 1964
| MGIid = 1928901
| Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008022 |text = protein C-terminus binding}} {{GNF_GO|id=GO:0030165 |text = PDZ domain binding}}
| Component =
| Process = {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0015893 |text = drug transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5174
| Hs_Ensembl =
| Hs_RefseqProtein = XP_001126677
| Hs_RefseqmRNA = XM_001126677
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 59020
| Mm_Ensembl = ENSMUSG00000038298
| Mm_RefseqmRNA = NM_021517
| Mm_RefseqProtein = NP_067492
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 96935635
| Mm_GenLoc_end = 96955568
| Mm_Uniprot = Q9JIL4
}}
}}
'''PDZ domain containing 1''', also known as '''PDZK1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on POLK... {November 10, 2007 1:49:46 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein POLK image.jpg {November 10, 2007 1:50:06 PM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 1:50:26 PM PST}
- CREATED: Created new protein page: POLK {November 10, 2007 1:50:35 PM PST}
- INFO: Beginning work on PPP1CB... {November 10, 2007 1:32:29 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PPP1CB image.jpg {November 10, 2007 1:32:46 PM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 1:33:00 PM PST}
- CREATED: Created new protein page: PPP1CB {November 10, 2007 1:33:08 PM PST}
- INFO: Beginning work on PPP1R12A... {November 10, 2007 1:27:27 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PPP1R12A image.jpg {November 10, 2007 1:28:41 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 1:28:55 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PPP1R12A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1s70.
| PDB = {{PDB2|1s70}}
| Name = Protein phosphatase 1, regulatory (inhibitor) subunit 12A
| HGNCid = 7618
| Symbol = PPP1R12A
| AltSymbols =; MBS; MGC133042; MYPT1
| OMIM = 602021
| ECnumber =
| Homologene = 1855
| MGIid = 1309528
| GeneAtlas_image1 = PBB_GE_PPP1R12A_201603_at_tn.png
| GeneAtlas_image2 = PBB_GE_PPP1R12A_201602_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_PPP1R12A_201604_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}}
| Component = {{GNF_GO|id=GO:0015629 |text = actin cytoskeleton}}
| Process = {{GNF_GO|id=GO:0006937 |text = regulation of muscle contraction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4659
| Hs_Ensembl = ENSG00000058272
| Hs_RefseqProtein = NP_002471
| Hs_RefseqmRNA = NM_002480
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 78692317
| Hs_GenLoc_end = 78853366
| Hs_Uniprot = O14974
| Mm_EntrezGene = 17931
| Mm_Ensembl = ENSMUSG00000019907
| Mm_RefseqmRNA = XM_001004092
| Mm_RefseqProtein = XP_001004092
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 107566510
| Mm_GenLoc_end = 107681685
| Mm_Uniprot = Q05A74
}}
}}
'''Protein phosphatase 1, regulatory (inhibitor) subunit 12A''', also known as '''PPP1R12A''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase.<ref>{{cite web | title = Entrez Gene: PPP1R12A protein phosphatase 1, regulatory (inhibitor) subunit 12A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4659| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Somlyo AP, Wu X, Walker LA, Somlyo AV |title=Pharmacomechanical coupling: the role of calcium, G-proteins, kinases and phosphatases. |journal=Rev. Physiol. Biochem. Pharmacol. |volume=134 |issue= |pages= 201-34 |year= 1999 |pmid= 10087910 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PPP2R2A... {November 10, 2007 1:33:08 PM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 1:33:33 PM PST}
- CREATED: Created new protein page: PPP2R2A {November 10, 2007 1:33:43 PM PST}
- INFO: Beginning work on PTGER2... {November 10, 2007 1:34:49 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 1:35:22 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Prostaglandin E receptor 2 (subtype EP2), 53kDa
| HGNCid = 9594
| Symbol = PTGER2
| AltSymbols =; EP2
| OMIM = 176804
| ECnumber =
| Homologene = 739
| MGIid = 97794
| GeneAtlas_image1 = PBB_GE_PTGER2_206631_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004957 |text = prostaglandin E receptor activity}} {{GNF_GO|id=GO:0004960 |text = thromboxane receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5732
| Hs_Ensembl = ENSG00000125384
| Hs_RefseqProtein = NP_000947
| Hs_RefseqmRNA = NM_000956
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 14
| Hs_GenLoc_start = 51850863
| Hs_GenLoc_end = 51865062
| Hs_Uniprot = P43116
| Mm_EntrezGene = 19217
| Mm_Ensembl = ENSMUSG00000037759
| Mm_RefseqmRNA = NM_008964
| Mm_RefseqProtein = NP_032990
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 43910072
| Mm_GenLoc_end = 43925090
| Mm_Uniprot = Q3UW60
}}
}}
'''Prostaglandin E receptor 2 (subtype EP2), 53kDa''', also known as '''PTGER2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PVRL1... {November 10, 2007 1:35:22 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 1:37:36 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Poliovirus receptor-related 1 (herpesvirus entry mediator C; nectin)
| HGNCid = 9706
| Symbol = PVRL1
| AltSymbols =; PRR1; CD111; CLPED1; ED4; HIgR; HVEC; MGC142031; MGC16207; OFC7; PRR; PVRR; PVRR1; SK-12; nectin-1
| OMIM = 600644
| ECnumber =
| Homologene = 2138
| MGIid = 1926483
| GeneAtlas_image1 = PBB_GE_PVRL1_208455_at_tn.png
| GeneAtlas_image2 = PBB_GE_PVRL1_211846_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_PVRL1_211845_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0015026 |text = coreceptor activity}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}}
| Component = {{GNF_GO|id=GO:0005913 |text = cell-cell adherens junction}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007156 |text = homophilic cell adhesion}} {{GNF_GO|id=GO:0007157 |text = heterophilic cell adhesion}} {{GNF_GO|id=GO:0046718 |text = entry of virus into host cell}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5818
| Hs_Ensembl = ENSG00000110400
| Hs_RefseqProtein = NP_002846
| Hs_RefseqmRNA = NM_002855
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 119014018
| Hs_GenLoc_end = 119104645
| Hs_Uniprot = Q15223
| Mm_EntrezGene = 58235
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_021424
| Mm_RefseqProtein = NP_067399
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Poliovirus receptor-related 1 (herpesvirus entry mediator C; nectin)''', also known as '''PVRL1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SAFB... {November 10, 2007 1:37:36 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 1:39:01 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Scaffold attachment factor B
| HGNCid = 10520
| Symbol = SAFB
| AltSymbols =; HET; HAP; DKFZp779C1727; SAFB1
| OMIM = 602895
| ECnumber =
| Homologene = 2229
| MGIid = 2146974
| GeneAtlas_image1 = PBB_GE_SAFB_201748_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SAFB_201747_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003690 |text = double-stranded DNA binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006325 |text = establishment and/or maintenance of chromatin architecture}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6294
| Hs_Ensembl = ENSG00000160633
| Hs_RefseqProtein = NP_002958
| Hs_RefseqmRNA = NM_002967
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 5574164
| Hs_GenLoc_end = 5619488
| Hs_Uniprot = Q15424
| Mm_EntrezGene = 224903
| Mm_Ensembl = ENSMUSG00000071054
| Mm_RefseqmRNA = XM_001002609
| Mm_RefseqProtein = XP_001002609
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 56270255
| Mm_GenLoc_end = 56291399
| Mm_Uniprot =
}}
}}
'''Scaffold attachment factor B''', also known as '''SAFB''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a DNA-binding protein that has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. This encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of the heat shock protein 27 transcription and also can act as an estrogen receptor corepressor. This gene is a candidate gene for breast tumorigenesis.<ref>{{cite web | title = Entrez Gene: SAFB scaffold attachment factor B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6294| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Oesterreich S |title=Scaffold attachment factors SAFB1 and SAFB2: Innocent bystanders or critical players in breast tumorigenesis? |journal=J. Cell. Biochem. |volume=90 |issue= 4 |pages= 653-61 |year= 2004 |pmid= 14587024 |doi= 10.1002/jcb.10685 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SDCBP... {November 10, 2007 1:39:01 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein SDCBP image.jpg {November 10, 2007 1:39:35 PM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 1:39:55 PM PST}
- CREATED: Created new protein page: SDCBP {November 10, 2007 1:40:05 PM PST}
- INFO: Beginning work on SOX10... {November 10, 2007 1:40:38 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 1:41:44 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = SRY (sex determining region Y)-box 10
| HGNCid = 11190
| Symbol = SOX10
| AltSymbols =; DOM; MGC15649; WS4
| OMIM = 602229
| ECnumber =
| Homologene = 5055
| MGIid = 98358
| GeneAtlas_image1 = PBB_GE_SOX10_209842_at_tn.png
| GeneAtlas_image2 = PBB_GE_SOX10_209843_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003682 |text = chromatin binding}} {{GNF_GO|id=GO:0003705 |text = RNA polymerase II transcription factor activity, enhancer binding}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}} {{GNF_GO|id=GO:0009653 |text = anatomical structure morphogenesis}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0048469 |text = cell maturation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6663
| Hs_Ensembl = ENSG00000100146
| Hs_RefseqProtein = NP_008872
| Hs_RefseqmRNA = NM_006941
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 22
| Hs_GenLoc_start = 36698254
| Hs_GenLoc_end = 36713375
| Hs_Uniprot = P56693
| Mm_EntrezGene = 20665
| Mm_Ensembl = ENSMUSG00000033006
| Mm_RefseqmRNA = XM_001001494
| Mm_RefseqProtein = XP_001001494
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 78982186
| Mm_GenLoc_end = 78992495
| Mm_Uniprot = Q80V12
}}
}}
'''SRY (sex determining region Y)-box 10''', also known as '''SOX10''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease.<ref>{{cite web | title = Entrez Gene: SOX10 SRY (sex determining region Y)-box 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6663| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ST6GAL1... {November 10, 2007 1:40:05 PM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 1:40:29 PM PST}
- CREATED: Created new protein page: ST6GAL1 {November 10, 2007 1:40:37 PM PST}
- INFO: Beginning work on STK4... {November 10, 2007 1:41:44 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein STK4 image.jpg {November 10, 2007 1:42:49 PM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 1:43:04 PM PST}
- CREATED: Created new protein page: STK4 {November 10, 2007 1:43:13 PM PST}
- INFO: Beginning work on SULT1A3... {November 10, 2007 1:43:13 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein SULT1A3 image.jpg {November 10, 2007 1:43:27 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 1:44:01 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SULT1A3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1cjm.
| PDB = {{PDB2|1cjm}}, {{PDB2|1ls6}}, {{PDB2|1z28}}, {{PDB2|1z29}}, {{PDB2|2a3r}}, {{PDB2|2d06}}
| Name = Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
| HGNCid = 11455
| Symbol = SULT1A3
| AltSymbols =; HAST; HAST3; M-PST; MGC117469; ST1A5; STM; SULT1A4; TL-PST
| OMIM = 600641
| ECnumber =
| Homologene = 81075
| MGIid =
| Function = {{GNF_GO|id=GO:0004062 |text = aryl sulfotransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006584 |text = catecholamine metabolic process}} {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0008202 |text = steroid metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6818
| Hs_Ensembl =
| Hs_RefseqProtein = XP_001126153
| Hs_RefseqmRNA = XM_001126153
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3''', also known as '''SULT1A3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16; this gene and SULT1A4 arose from a segmental duplication. This gene is the most centromeric of the four sulfotransferase genes. Exons of this gene overlap with exons of a gene that encodes a protein containing GIY-YIG domains (GIYD1). Three alternatively spliced variants that encode the same protein have been described.<ref>{{cite web | title = Entrez Gene: SULT1A3 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6818| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Weinshilboum RM, Otterness DM, Aksoy IA, ''et al.'' |title=Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes. |journal=FASEB J. |volume=11 |issue= 1 |pages= 3-14 |year= 1997 |pmid= 9034160 |doi= }}
*{{cite journal | author=Glatt H, Engelke CE, Pabel U, ''et al.'' |title=Sulfotransferases: genetics and role in toxicology. |journal=Toxicol. Lett. |volume=112-113 |issue= |pages= 341-8 |year= 2000 |pmid= 10720750 |doi= }}
*{{cite journal | author=Glatt H |title=Sulfotransferases in the bioactivation of xenobiotics. |journal=Chem. Biol. Interact. |volume=129 |issue= 1-2 |pages= 141-70 |year= 2001 |pmid= 11154739 |doi= }}
*{{cite journal | author=Glatt H, Boeing H, Engelke CE, ''et al.'' |title=Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects. |journal=Mutat. Res. |volume=482 |issue= 1-2 |pages= 27-40 |year= 2001 |pmid= 11535246 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TAF6... {November 10, 2007 1:44:01 PM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 1:44:51 PM PST}
- CREATED: Created new protein page: TAF6 {November 10, 2007 1:45:01 PM PST}
- INFO: Beginning work on TAF7... {November 10, 2007 1:45:01 PM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 1:45:38 PM PST}
- CREATED: Created new protein page: TAF7 {November 10, 2007 1:45:46 PM PST}
- INFO: Beginning work on TCF4... {November 10, 2007 1:45:47 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 1:47:15 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Transcription factor 4
| HGNCid = 11634
| Symbol = TCF4
| AltSymbols =; E2-2; ITF2; MGC149723; MGC149724; SEF2; SEF2-1; SEF2-1A; SEF2-1B
| OMIM = 602272
| ECnumber =
| Homologene = 2407
| MGIid = 98506
| GeneAtlas_image1 = PBB_GE_TCF4_203753_at_tn.png
| GeneAtlas_image2 = PBB_GE_TCF4_212382_at_tn.png
| GeneAtlas_image3 = PBB_GE_TCF4_222146_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6925
| Hs_Ensembl = ENSG00000196628
| Hs_RefseqProtein = NP_003190
| Hs_RefseqmRNA = NM_003199
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 18
| Hs_GenLoc_start = 51046093
| Hs_GenLoc_end = 51406858
| Hs_Uniprot = P15884
| Mm_EntrezGene = 21413
| Mm_Ensembl = ENSMUSG00000053477
| Mm_RefseqmRNA = NM_013685
| Mm_RefseqProtein = NP_038713
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 18
| Mm_GenLoc_start = 69469890
| Mm_GenLoc_end = 69809713
| Mm_Uniprot = Q91XK1
}}
}}
'''Transcription factor 4''', also known as '''TCF4''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes transcription factor 4, a basic helix-turn-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is expressed predominantly in pre-B-cells, although it is found in other tissues as well. Multiple alternatively spliced transcript variants that encode different proteins have been described.<ref>{{cite web | title = Entrez Gene: TCF4 transcription factor 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6925| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Bain G, Murre C |title=The role of E-proteins in B- and T-lymphocyte development. |journal=Semin. Immunol. |volume=10 |issue= 2 |pages= 143-53 |year= 1998 |pmid= 9618760 |doi= 10.1006/smim.1998.0116 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TDG... {November 10, 2007 1:47:15 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein TDG image.jpg {November 10, 2007 1:47:59 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 1:48:09 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TDG_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1wyw.
| PDB = {{PDB2|1wyw}}, {{PDB2|2d07}}
| Name = Thymine-DNA glycosylase
| HGNCid = 11700
| Symbol = TDG
| AltSymbols =;
| OMIM = 601423
| ECnumber =
| Homologene = 2415
| MGIid =
| GeneAtlas_image1 = PBB_GE_TDG_203743_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003684 |text = damaged DNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008263 |text = pyrimidine-specific mismatch base pair DNA N-glycosylase activity}} {{GNF_GO|id=GO:0016798 |text = hydrolase activity, acting on glycosyl bonds}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005654 |text = nucleoplasm}}
| Process = {{GNF_GO|id=GO:0006284 |text = base-excision repair}} {{GNF_GO|id=GO:0008152 |text = metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6996
| Hs_Ensembl = ENSG00000139372
| Hs_RefseqProtein = NP_003202
| Hs_RefseqmRNA = NM_003211
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 102883747
| Hs_GenLoc_end = 102906785
| Hs_Uniprot = Q13569
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Thymine-DNA glycosylase''', also known as '''TDG''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.<ref>{{cite web | title = Entrez Gene: TDG thymine-DNA glycosylase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6996| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Lindahl T |title=DNA repair enzymes. |journal=Annu. Rev. Biochem. |volume=51 |issue= |pages= 61-87 |year= 1982 |pmid= 6287922 |doi= 10.1146/annurev.bi.51.070182.000425 }}
*{{cite journal | author=Hardeland U, Bentele M, Lettieri T, ''et al.'' |title=Thymine DNA glycosylase. |journal=Prog. Nucleic Acid Res. Mol. Biol. |volume=68 |issue= |pages= 235-53 |year= 2001 |pmid= 11554300 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TLE1... {November 10, 2007 1:48:09 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein TLE1 image.jpg {November 10, 2007 1:49:28 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 1:49:46 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TLE1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1gxr.
| PDB = {{PDB2|1gxr}}, {{PDB2|2ce8}}, {{PDB2|2ce9}}
| Name = Transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
| HGNCid = 11837
| Symbol = TLE1
| AltSymbols =; ESG; ESG1; GRG1
| OMIM = 600189
| ECnumber =
| Homologene = 21058
| MGIid = 104636
| GeneAtlas_image1 = PBB_GE_TLE1_203221_at_tn.png
| GeneAtlas_image2 = PBB_GE_TLE1_203220_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_TLE1_203222_s_at_tn.png
| Function = {{GNF_GO|id=GO:0008134 |text = transcription factor binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007222 |text = Wnt receptor signaling pathway}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}} {{GNF_GO|id=GO:0030178 |text = negative regulation of Wnt receptor signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7088
| Hs_Ensembl = ENSG00000196781
| Hs_RefseqProtein = NP_005068
| Hs_RefseqmRNA = NM_005077
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 83388418
| Hs_GenLoc_end = 83494270
| Hs_Uniprot = Q04724
| Mm_EntrezGene = 21885
| Mm_Ensembl = ENSMUSG00000008305
| Mm_RefseqmRNA = XM_984048
| Mm_RefseqProtein = XP_989142
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 71603503
| Mm_GenLoc_end = 71687218
| Mm_Uniprot = Q5SQA2
}}
}}
'''Transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)''', also known as '''TLE1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Eastman Q, Grosschedl R |title=Regulation of LEF-1/TCF transcription factors by Wnt and other signals. |journal=Curr. Opin. Cell Biol. |volume=11 |issue= 2 |pages= 233-40 |year= 1999 |pmid= 10209158 |doi= }}
}}
{{refend}}
{{protein-stub}}
end log.
